Olfactory transmucosal – Coronavirus ( Covid-19) entry point to the brain?
Nature featured ‘Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19’
[ From the abstract] The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a pandemic respiratory disease. Moreover, thromboembolic events throughout the body, including in the CNS, have been described. Given the neurological symptoms observed in a large majority of individuals with COVID-19, SARS-CoV-2 penetrance of the CNS is likely. By various means, we demonstrate the presence of SARS-CoV-2 RNA and protein in anatomically distinct regions of the nasopharynx and brain.
Furthermore, we describe the morphological changes associated with infection such as thromboembolic ischemic infarction of the CNS and present evidence of SARS-CoV-2 neurotropism. SARS-CoV-2 can enter the nervous system by crossing the neural–mucosal interface in olfactory mucosa, exploiting the close vicinity of olfactory mucosal, endothelial and nervous tissue, including delicate olfactory and sensory nerve endings. Subsequently, SARS-CoV-2 appears to follow neuroanatomical structures, penetrating defined neuroanatomical areas including the primary respiratory and cardiovascular control center in the medulla oblongata.
- Smelling Trouble: Olfactory Dysfunction Linked to Higher Cardiovascular Risk
- U-Smell-It honored in global $6M XPRIZE Rapid Covid Testing Competition
- Smell problems are finally being recognised as serious diseases – by ThePrint
- Long-term loss of smell could make people feel depressed, how to recover from it
- Nation Africa featured our smell test – ‘What if there was a less irritating way to test for Covid?’